Discovering the Function of an Unknown Protein Using Bioinformatics Tools
Location
CoLab, COM 100
Start Date
1-5-2025 5:30 PM
Document Type
Poster
Description
Thousands of protein structures in the Protein Database lack assigned functions. Our project aims to analyze a chosen protein to determine whether it is structural or catalytic. If catalytic, we will identify the type of reaction it catalyzes. This bioinformatics-based project will utilize computational tools to analyze protein sequences and structures: Protein Database – Provides protein descriptions, origin, and structural details. BLAST – Identifies proteins with similar sequences to infer potential functions. InterPro – Detects conserved protein domains and classifies protein families. DALI – Compares 3D protein structures for functional insights. FoldSeek – Similar to DALI but uses different algorithms to confirm results. CLEAN – Identifies enzymatic families. Google Slides – Used for compiling and presenting findings. Through this project, we aim to: -Identify and hypothesize the function of unknown proteins. -Gain experience using bioinformatics tools for protein analysis. -Understand the role of structural biology and computational methods in functional annotation. -Explore applications of protein function research in drug discovery, classification, and biology.
Discovering the Function of an Unknown Protein Using Bioinformatics Tools
CoLab, COM 100
Thousands of protein structures in the Protein Database lack assigned functions. Our project aims to analyze a chosen protein to determine whether it is structural or catalytic. If catalytic, we will identify the type of reaction it catalyzes. This bioinformatics-based project will utilize computational tools to analyze protein sequences and structures: Protein Database – Provides protein descriptions, origin, and structural details. BLAST – Identifies proteins with similar sequences to infer potential functions. InterPro – Detects conserved protein domains and classifies protein families. DALI – Compares 3D protein structures for functional insights. FoldSeek – Similar to DALI but uses different algorithms to confirm results. CLEAN – Identifies enzymatic families. Google Slides – Used for compiling and presenting findings. Through this project, we aim to: -Identify and hypothesize the function of unknown proteins. -Gain experience using bioinformatics tools for protein analysis. -Understand the role of structural biology and computational methods in functional annotation. -Explore applications of protein function research in drug discovery, classification, and biology.
Comments
The faculty mentor for this project was Faith Jacobsen, Chemistry.