Location
CoLab, OCB 100
Start Date
25-4-2024 6:00 PM
Document Type
Poster
Description
Antimicrobial peptides (AMP), due to their broad inhibitory effects on common pathogenic bacteria, are a growing area of interest within the pharmaceutical industry. In this project, two amino acids, alanine and phenylalanine, will be coupled in order to produce a dipeptide. Protecting the N-terminus of the phenylalanine with a tert-butyloxycarbonyl (BOC) group and the C-terminus of the alanine as a methyl ester allows only one type of dipeptide to form. The antimicrobial activity of the synthesized dipeptide will be evaluated and compared to other dipeptides currently understood to have antimicrobial activity.
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Alanine-Phenylalanine Dipeptide Synthesis and Antimicrobial Evaluation
CoLab, OCB 100
Antimicrobial peptides (AMP), due to their broad inhibitory effects on common pathogenic bacteria, are a growing area of interest within the pharmaceutical industry. In this project, two amino acids, alanine and phenylalanine, will be coupled in order to produce a dipeptide. Protecting the N-terminus of the phenylalanine with a tert-butyloxycarbonyl (BOC) group and the C-terminus of the alanine as a methyl ester allows only one type of dipeptide to form. The antimicrobial activity of the synthesized dipeptide will be evaluated and compared to other dipeptides currently understood to have antimicrobial activity.
Comments
The faculty mentor for this project was Meagan Weldele, Chemistry.