Dendritic Cells in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) persists as a chronic inflammatory autoimmune disease and is characterized by the production of autoantibodies and immune complexes that affects multiple organs. The underlying mechanism that triggers and sustain disease are complex and involves certain susceptibility genes and environmental factors. There have been several immune mediators linked to SLE including cytokines and chemokines that have been reviewed elsewhere. A number of articles have reviewed the role of B cells and T cells in SLE. Here, we focus on role of dendritic cells (DC) and innate immune factors that may regulate autoreactive B cells.
Seitz, Heather M. and Matsushima, Glenn K., "Dendritic Cells in Systemic Lupus Erythematosus" (2010). Biology Papers and Presentations. Paper 1.