Title

Dendritic Cells in Systemic Lupus Erythematosus

Comments

This version, the provided abstract, and author information appears as archived at the National Institute of Health's public access area in PubMed Central. The final version of this paper appeared in the journal, International Reviews of Immunology, April 2010, Volume 29, Number 2, pages 184-209.

Abstract

Systemic lupus erythematosus (SLE) persists as a chronic inflammatory autoimmune disease and is characterized by the production of autoantibodies and immune complexes that affects multiple organs. The underlying mechanism that triggers and sustain disease are complex and involves certain susceptibility genes and environmental factors. There have been several immune mediators linked to SLE including cytokines and chemokines that have been reviewed elsewhere. A number of articles have reviewed the role of B cells and T cells in SLE. Here, we focus on role of dendritic cells (DC) and innate immune factors that may regulate autoreactive B cells.